Why the study?
Does high-frequency rTMS improve symptoms in patients with benzodiazepine non-responsive catatonia?
Does high-frequency rTMS improve symptoms in patients with benzodiazepine non-responsive catatonia?
High-frequency rTMS may be an effective treatment for benzodiazepine non-responsive catatonia in patients with mood disorders, though it may worsen symptoms in those with chronic resistant schizophrenia.
rTMS responses varied by diagnosis in refractory catatonia; hypothesis-generating and requires controlled trials before any clinical consideration.
Four patients with benzodiazepine non-responsive catatonia were administered repetitive transcranial magnetic stimulation (rTMS) at the left dorsolateral prefrontal cortex at 120% of resting motor threshold, frequency of 10Hz, with a total of 3,000 pulses/session. Patients with mood disorders showed good responses. One patient with chronic resistant schizophrenia had worsening catatonic symptoms during rTMS that responded to electroconvulsive therapy. Maximum response was observed between sessions 8 and 12.
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Rizvi et al. (2023) studied this question.
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