Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 1, 1997Acta Anaesthesiologica Scandinavica

4‐chloro‐m‐cresol test ‐ a possible supplementary test for diagnosis of malignant hyperthermia susceptibility

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does 4-chloro-m-cresol testing accurately diagnose malignant hyperthermia susceptibility in muscle biopsies?

Population

Muscle from 41 consecutive patients from 7 families undergoing diagnostic muscle biopsy with in vitro…

Comparison

In vitro exposure to increasing concentrations… vs Standard halothane and caffeine tests

Design

Other

Authors

HØHelle ØrdingUniversity of Southern DenmarkKGKlaus P.E. GlahnHerlev HospitalTGT. i GardiUniversity of Copenhagen

Discussion

Loading...

Member takes

Implication

May support chlorocresol testing as supplementary MH diagnostic; leaves open routine adoption pending prospective validation.

Structured PICO

Does 4-chloro-m-cresol testing accurately diagnose malignant hyperthermia susceptibility in muscle biopsies?

P
Population
Muscle from 41 consecutive patients from 7 families undergoing diagnostic muscle biopsy with in vitro contracture test (IVCT)
I
Intervention
In vitro exposure to increasing concentrations of 4-chloro-m-cresol (25, 50, 75, 100, 150, and 200 mumol l-1)
C
Comparator
Standard halothane and caffeine tests (used to classify patients as MH susceptible or MH negative)
O
Outcome
Force development and threshold concentration for increasing forcesurrogate

4-chloro-m-cresol is a highly accurate supplementary in vitro test for diagnosing malignant hyperthermia susceptibility.

Cite This Study

Ørding et al. (1997) studied this question.

synapsesocial.com/papers/6a703dc2f44fa9f079ddd1f3https://doi.org/10.1111/j.1399-6576.1997.tb04821.x
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Detection of a novel common mutation in the ryanodine receptor gene in malignant hyperthermia: implications for diagnosis and heterogeneity studies1994 · 112 citations
  2. 2Detection of a novel RYR1 mutation in four malignant hyperthermia pedigrees1994 · 81 citations
  3. 3Chlorocresol, an Additive to Commercial Succinylcholine, Induces Contracture of Human Malignant Hyperthermia-susceptible Muscles Via Activation of the Ryanodine Receptor Calcium sup 2+ Channel1996 · 58 citations
  4. 4Results of in vitro contracture testing of both parents of malignant hyperthermia susceptible probands1996 · 18 citations