Why the study?
Do anaesthetics with triggering agents cause malignant hyperthermia in patients diagnosed as Malignant Hyperthermia Negative (MHN) and their children?
Do anaesthetics with triggering agents cause malignant hyperthermia in patients diagnosed as Malignant Hyperthermia Negative (MHN) and their children?
A small observational study found no cases of malignant hyperthermia in MHN patients exposed to triggering agents, though the sample size was insufficient to definitively confirm the reliability of the in vitro contracture test.
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Should not yet change practice for MHN patients; leaves open the reliability of negative in vitro contracture testing.
In vitro contracture test is still the most reliable method for diagnosing malignant hyperthermia susceptibility. In order to investigate the reliability of Malignant Hyperthermia Negative (MHN) results, a questionnaire was sent to 237 persons of whom 133 were consecutively investigated and found to be MHN, together with 104 of their children. In 17 anaesthetics with triggering agents in 7 MHN patients and 7 children of MHN patients, no signs of malignant hyperthermia were observed in any patient. This material is, however, too small to draw any conclusion about the reliability of MHN test results. This can only be done in a large multicentre study or a metaanalysis of several studies.
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Islander et al. (1995) studied this question.
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