Population
Individuals susceptible to malignant hyperthermia
Comparison
DNA testing for malignant hyperthermia… vs In vitro contracture tests (caffeine-halothane)
Design
Review
Authors
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DNA testing cannot supplant in vitro contracture testing for MH; leaves open broader genetic diagnosis pending functional validation of variants.
While DNA testing for malignant hyperthermia is widespread for known mutations, it cannot yet replace invasive in vitro contracture tests due to genetic heterogeneity and the need for functional validation of new variants.
Kathryn M. Stowell (2014) studied this question.
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