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Synthesize emerging insights into metabolic adaptations in non-small cell lung cancer beyond the Warburg effect and evaluate novel metabolic vulnerabilities for therapeutic targeting.

May 21, 2025Frontiers in OncologyOpen Access

Metabolic reprogramming and therapeutic targeting in non-small cell lung cancer: emerging insights beyond the Warburg effect

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Synthesize emerging insights into metabolic adaptations in non-small cell lung cancer beyond the Warburg effect and evaluate novel metabolic vulnerabilities for therapeutic targeting.
Narrative review synthesizing findings on altered lipid metabolism, amino acid pathways, and tumor microenvironment crosstalk in non-small cell lung cancer.
Evaluation of emerging metabolic profiling technologies, including single-cell and spatial metabolomics, for identifying therapeutic targets.
Tumor progression and therapy resistance are driven by diverse metabolic alterations extending beyond glycolysis, including shifted lipid processing and amino acid dependencies.
Metabolic crosstalk and heterogeneity within the tumor microenvironment contribute to treatment failure and define actionable vulnerabilities for combination therapies.

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Narrative review reveals complex metabolic reprogramming beyond the Warburg effect in non-small cell lung cancer, highlighting novel therapeutic targets.

Cite This Study

Cai et al. (2025) studied this question.

synapsesocial.com/papers/6a703e94ac440176ef28e4b3 https://doi.org/10.3389/fonc.2025.1564226

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Implication

Narrative review reveals complex metabolic reprogramming beyond the Warburg effect in non-small cell lung cancer, highlighting novel therapeutic targets.

Metabolic reprogramming and therapeutic targeting in non-small cell lung cancer: emerging insights beyond the Warburg effect

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Discussion

Implication

Cite This Study

Metabolic reprogramming and therapeutic targeting in non-small cell lung cancer: emerging insights beyond the Warburg effect

Key Points

Discussion

Implication

Cite This Study

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