January 1, 2012Thrombosis and Haemostasis
Prevalence of poor biological response to clopidogrel
Why the study?
What is the prevalence of poor biological response to clopidogrel across different platelet function assays?
Population
171 publications providing data for a total of 45,664 subjects
Design
Meta-analysis
Authors
Discussion
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Member takes
Implication
Clopidogrel poor-response prevalence varies widely by assay; challenges standardization of platelet function testing in research and practice.
Structured PICO
What is the prevalence of poor biological response to clopidogrel across different platelet function assays?
P
Population
171 publications providing data for a total of 45,664 subjects
I
Intervention
Clopidogrel
O
Outcome
Prevalence of poor biological response to clopidogrelsurrogate
The prevalence of poor biological response to clopidogrel is highly variable (15.9% to 49.5%) and depends heavily on the specific platelet function assay and cut-off values used.
Cite This Study
Labruyère et al. (2012) studied this question.