October 30, 2014European Respiratory Journal

An international ISHLT/ATS/ERS clinical practice guideline: diagnosis and management of bronchiolitis obliterans syndrome

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Population

Patients with or at risk for bronchiolitis obliterans syndrome (BOS) following lung transplantation

Design

Guideline

Authors

KMKeith C. MeyerUniversity of Wisconsin–Madison GRGanesh RaghuUniversity of Minnesota GVGeert M. VerledenAntwerp University Hospital

Discussion

Member takes

Implication

No proven benefit from current BOS therapies; guideline extends consensus definitions and management while highlighting evidence gaps.

Structured PICO

Population

Patients with or at risk for bronchiolitis obliterans syndrome (BOS) following lung transplantation

Intervention

Management and prevention strategies including systemic corticosteroids, cyclosporine, tacrolimus, azithromycin, and re-transplantation

This international guideline provides updated definitions, risk factors, and recommendations for the diagnosis and management of bronchiolitis obliterans syndrome following lung transplantation.

Limitations

Lack of proven significant benefit from currently available therapies
Need for adequately designed and executed randomised controlled trials

Cite This Study

Meyer et al. (2014) studied this question.

synapsesocial.com/papers/6a703ff9c1a24a6142db785e https://doi.org/10.1183/09031936.00107514

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