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February 1, 2007European Journal of Cardiovascular Prevention & RehabilitationOpen Access

The effect of endurance training on exercise capacity following cardiac resynchronization therapy in chronic heart failure patients: a pilot trial

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Why the study?

Does endurance training improve exercise capacity in patients with chronic heart failure and dyssynchrony receiving cardiac resynchronization therapy?

Population

36 patients with chronic heart failure and dyssynchrony. Randomized cohort: mean age 59+/-9 years, 8 men.

Comparison

Endurance training in addition to cardiac… vs CRT without ET, standard care with ET, and…

Design

RCT, randomized

Follow-up

5 months

Authors

VCViviane M. ConraadsHeart Failure & TransplantMVMarc VanderheydenOnze Lieve Vrouwziekenhuis Hospital
Bernard P. Paelinck
Bernard P. PaelinckCardiac Imaging

Discussion

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Overview

Supports adding endurance training to CRT in chronic HF; extends device-only trials with additive functional gains.

Structured PICO

Does endurance training improve exercise capacity in patients with chronic heart failure and dyssynchrony receiving cardiac resynchronization therapy?

P
Population
36 patients with chronic heart failure and dyssynchrony (17 randomized to CRT +/- ET, 19 matched controls). Randomized cohort: mean age 59+/-9 years, 8 men.
I
Intervention
Endurance training (ET) in addition to cardiac resynchronization therapy (CRT)
C
Comparator
CRT without ET, standard care with ET, and standard care only
O
Outcome
Exercise tolerance (VO2peak, Wattmax, circulatory power) at 5 monthssurrogate

Endurance training added to cardiac resynchronization therapy significantly improves exercise capacity compared to CRT alone in patients with chronic heart failure.

Cite This Study

Conraads et al. (2007) studied this question.

synapsesocial.com/papers/6a70400326a7f98052dcbfd2https://doi.org/10.1097/hjr.0b013e32801164b3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiac Resynchronization in Chronic Heart Failure2002 · 4,614 citations
  2. 2Exercise training in heart failure improves quality of life and exercise capacity1998 · 172 citations
  3. 3A Meta-Analysis of the Effect of Angiotensin-Converting Enzyme Inhibitors on Functional Capacity in Patients with Symptomatic Left Ventricular Systolic Dysfunction2004 · 28 citations
  4. 4Adverse Mortality Effect of Central Sympathetic Inhibition with Sustained-Release Moxonidine in Patients with Heart Failure (MOXCON)2003 · 384 citations
  5. 5Antiremodeling Effect of Long-Term Exercise Training in Patients With Stable Chronic Heart Failure2003 · 342 citations