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August 3, 2026Animal nutritionOpen Access

A tributyrin-monolaurin complex protects piglets against PEDV infection via viral inhibition, lipid metabolism restoration, and microbiota modulation

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Authors

ZSZhuan SongHXHuanhuan XuHRHongli Ren

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Overview

Randomized trial evaluates tributyrin-monolaurin complex's effects on PEDV infection, indicating potential health benefits for piglets.

Key Points

  • This study investigates the efficacy of a tributyrin-monolaurin complex against PEDV infection in piglets and its underlying protective mechanisms.
  • PEDV-infected Vero cells treated with GML and TB to assess antiviral effects.
  • Thirty 7-day-old piglets assigned to groups for treatment with the PE complex or control.
  • Microencapsulated PE administered orally for 7 days, followed by PEDV inoculation.
  • 40 μmol/L GML and 0.25 mmol/L TB reduced virus replication (P=0.023).
  • PE improved gene expression related to water transport, downregulated inflammatory markers (P<0.05).
  • PE restored lipid metabolism and altered gut microbiota composition significantly.

Cite This Study

Song et al. (2026) studied this question.

synapsesocial.com/papers/6a70402f75942ff7265e4e53https://doi.org/10.1016/j.aninu.2026.04.006
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