Randomized trial evaluates Klotho modulation and autophagy improvement in diabetic kidney disease, suggesting a new therapy approach.
Key Points
To investigate the effects of mesenchymal stem cells, empagliflozin, and calorie restriction on autophagy and Klotho modulation in diabetic kidney disease.
Male BTBRob/ob mice were used as a model for diabetes and diabetic kidney disease.
Mice were treated with MSCs, empagliflozin, and calorie restriction, then euthanized at specified weeks for analysis.
Kidney tissues were studied using qPCR, Western blot, and immunohistochemistry.