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August 3, 2026AJP Gastrointestinal and Liver PhysiologyOpen Access

Radiotherapy reduces ATP-mediated relaxation in human rectal smooth muscle

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Authors

YKYoon‐Hye KwonTSTae Sik SungYYYoung Hyun Yun

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Overview

Randomized trial reveals impaired relaxation in rectal muscle after radiotherapy, suggesting a new treatment pathway.

Key Points

  • This research aims to investigate the effects of radiotherapy on motility changes in human rectal smooth muscle and identify the underlying mechanisms.
  • Human rectal tissues were analyzed from patients with and without preoperative concurrent chemoradiotherapy (N=112);
  • Isometric tension recordings measured myogenic responses, while electrical field stimulation assessed neurogenic components;
  • Expression levels of interstitial cells, neuronal cells, and smooth muscle cells were quantified via immunohistochemistry and quantitative PCR.
  • ATP-induced relaxation and slow wave activity suppression were significantly reduced in irradiated rectal tissue (P < 0.001);
  • Expression levels of PDGFRα and Kit were markedly decreased in irradiated tissue, while NOS1, VAChT, and MYH11 remained unchanged;
  • Reduced PDGFRα⁺ cells and ICC correlated with decreased ATP-mediated responses, suggesting impaired rectal function post-radiotherapy.

Cite This Study

Kwon et al. (2026) studied this question.

synapsesocial.com/papers/6a70403e75942ff7265e50fdhttps://doi.org/10.1152/ajpgi.00451.2025
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Also Consider

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