Randomized trial explores plasma exchange effects on alveolar hemorrhage in ANCA-associated vasculitis, suggesting clinical implications for improved management.
For the clinician managing a patient with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and worsening diffuse alveolar hemorrhage (DAH), the decision to initiate plasma exchange (PLEX) remains one of the most consequential and least supported in the field. This presentation has a high early mortality especially when there is hypoxia or a requirement for mechanical ventilation.
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Uchida et al. (2026) studied this question.
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