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August 3, 2026The Journal of Rheumatology

Responsiveness of Patient-Reported Outcomes by Disease Trajectory in Systemic Lupus Erythematosus

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Authors

SHSabrina HundalUniversity of CalgaryJCJ. CappelliMcMaster UniversityMKMohammed KaouachePrince Sultan University

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Implication

Randomized trial evaluates patient-reported outcomes across disease trajectories in systemic lupus erythematosus, highlighting their importance.

Key Points

  • This research aims to evaluate the responsiveness of patient-reported outcomes across different disease trajectories in systemic lupus erythematosus (SLE).
  • Pooled patient-level data from 4 phase III belimumab trials (n=1065)
  • Participants were stratified into 4 disease trajectory classes based on disease activity and treatment response
  • Responsiveness of PROs was assessed using standardized response means (SRMs) and correlation analyses with clinical indices.
  • FACIT-F and SF-36 physical component scores were the most responsive, with FACIT-F showing peak responsiveness early on and SF-36 PCS later.
  • EQ-5D demonstrated the lowest responsiveness (peak SRM 0.54) and weakest correlations with clinical indices.
  • PGA had the strongest correlation with PRO changes, whereas SLEDAI-2K correlations were weak.

Cite This Study

Hundal et al. (2026) studied this question.

synapsesocial.com/papers/6a70404875942ff7265e533fhttps://doi.org/10.3899/jrheum.2026-0447.97
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