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To report a unique case of large vessel vasculitis and pachymeningitis possibly induced by lenalidomide in a patient with follicular lymphoma.

Lenalidomide-Induced Large Vessel Vasculitis and Pachymeningitis Complicating Treatment of Follicular Lymphoma: A Case Report

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To report a unique case of large vessel vasculitis and pachymeningitis possibly induced by lenalidomide in a patient with follicular lymphoma.
Case report of a 66-year-old male with relapsed follicular lymphoma
Monitored symptoms, imaging, and biochemical markers post-lenalidomide treatment
Conducted extensive microbiologic workup, lumbar puncture, and imaging studies.
Initial CRP of 255 mg/L normalized over 2 weeks alongside clinical improvement
Repeat imaging showed reduction in lymphadenopathy and near resolution of aortitis
No active large vessel vasculitis, meningitis, or malignancy detected on subsequent PET CT scan.

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Case report demonstrates lenalidomide causes large vessel vasculitis and pachymeningitis in lymphoma, suggesting novel side effects.

Mocanu et al. (2026) studied this question.

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