What question did this study set out to answer?

This research aims to evaluate the real-world effectiveness and safety of upadacitinib in Canadian patients with rheumatoid arthritis.

August 3, 2026The Journal of Rheumatology

Effectiveness of Upadacitinib in Patients with Rheumatoid Arthritis in Canadian Real-World Practice: Final Results from the Close-Up Post-Marketing Observational Study

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This research aims to evaluate the real-world effectiveness and safety of upadacitinib in Canadian patients with rheumatoid arthritis.
Prospective, observational post-marketing study across 33 Canadian sites
Followed adults with moderate-to-severe RA treated with upadacitinib 15 mg daily for 24 months
Primary endpoint assessed was the proportion achieving DAS28-CRP < 2.6 at 6 months.
60.7% of patients achieved DAS28-CRP < 2.6 at 6 months with continued effectiveness for 24 months
86.5% persisted on UPA treatment at 6 months; 67.5% at 24 months
Improvements were noted in pain, fatigue, and physical function scores, maintaining consistency across prior DMARD exposures.

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Implication

Observational study reveals effectiveness of Upadacitinib in reducing disease activity in Canadian patients with rheumatoid arthritis, suggesting strong real-world applicability.

Cite This Study

Bessette et al. (2026) studied this question.

synapsesocial.com/papers/6a70404875942ff7265e53d0 https://doi.org/10.3899/jrheum.2026-0447.9

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Implication

Observational study reveals effectiveness of Upadacitinib in reducing disease activity in Canadian patients with rheumatoid arthritis, suggesting strong real-world applicability.

Effectiveness of Upadacitinib in Patients with Rheumatoid Arthritis in Canadian Real-World Practice: Final Results from the Close-Up Post-Marketing Observational Study

Key Points

Discussion

Implication

Cite This Study

Effectiveness of Upadacitinib in Patients with Rheumatoid Arthritis in Canadian Real-World Practice: Final Results from the Close-Up Post-Marketing Observational Study

Key Points

Discussion

Implication

Cite This Study

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