A study of the coagulation mechanism in 34 cases of multiple myeloma has been made. Three patients exhibited the “gelation” phenomena, demonstrated to be due to binding of fibrin monomers by abnormal immunoglobulins. Systematic examination of hemostasis in the remaining cases showed both a thrombotic and a hemorrhagic tendency. Abnormal laboratory parameters of the former were: 1. shortened coagulation time, 2. increased fibrinogen levels, and 3. reduced antiplasmin levels. Hemorrhagic tendency was reflected in such laboratory results as: 1. reduced platelet adhesiveness, 2. prolonged thrombin time, 3. prolonged prothrombin time, and 4. increased fibrinolysis.
No takes yet. Share an insight, caveat, or question.
Sánchez-Ávalos et al. (1969) studied this question.
Synapse has enriched one closely related paper. Consider it for comparative context: