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Quercetin may protect renal tubules experimentally; leaves open any clinical role in ischemia-reperfusion AKI pending human trials.
HIGHLIGHTS Ischemia-reperfusion triggers acute kidney injury due to reactive oxygen species. Quercetin is an antioxidant flavonoid that modulate the Rennin-Angiotensin System. Quercetin prevents tubular cell death, oxidation, and mitochondrial depolarization. Quercetin interacts with the angiotensin AT1 receptor.
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Canuto et al. (2021) studied this question.
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