Population
Recombinant myosin head fragment of Dictyostelium discoideum and skeletal muscle myosin subfragment 1
Comparison
Interaction with actin and adenine nucleotides vs Skeletal muscle myosin subfragment 1 (S1)
Design
Preclinical
Authors
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Kinetic distinctions in nonmuscle myosin should not yet alter practice; leaves open extension to cardiac isoforms or therapeutic targeting.
The study reveals differences in the kinetic interactions of Dictyostelium discoideum myosin head fragments compared to skeletal muscle myosin, suggesting a different degree of coupling between nucleotide and actin binding sites in nonmuscle myosins.
Ritchie et al. (1993) studied this question.
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