Why the study?
Are apolipoprotein E and angiotensin-converting enzyme gene polymorphisms associated with healthy aging and longevity in a sex-dependent manner?
Are apolipoprotein E and angiotensin-converting enzyme gene polymorphisms associated with healthy aging and longevity in a sex-dependent manner?
ApoE and ACE gene polymorphisms are associated with healthy aging and longevity, with effects that appear to be sex-dependent.
ε2 enrichment in older men supports sex-specific longevity association; hypothesis-generating, should not yet change practice.
We investigated the association of sex and age with the occurrence of apolipoprotein E (apoE) and angiotensin-converting enzyme (ACE) genotypes in healthy aging and longevity in 1344 healthy individuals and 64 centenarians. As compared to participants younger than 60 years, a significant higher frequency of the apoE/epsilon2 was observed in men aged 60-90 years (p <.001) and in centenarians (p <.001). Logistic regression analysis confirmed this outcome in both participants aged 60-90 years (odds ratio [OR] = 1.897; 95% confidence interval [CI], 1.227-2.931) and centenarians (OR = 3.263; 95% CI, 1.860-5.722). A further significant association of ACE/D allele and age was observed in centenarians (OR = 2.135; 95% CI, 1.253-3.636). Heterosis was also observed at the ACE locus. No relationship between apoE and ACE polymorphism was found. These findings suggest a role of sex in the association of apoE and ACE gene polymorphisms with healthy aging and longevity.
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Seripa et al. (2006) studied this question.
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