August 1, 1995Circulation

Relation Between the Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Late Luminal Narrowing After Coronary Angioplasty

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Why the study?

Does the ACE gene I/D polymorphism influence the occurrence of restenosis after PTCA in patients with one-vessel disease?

Structured PICO

Does the ACE gene I/D polymorphism influence the occurrence of restenosis after PTCA in patients with one-vessel disease?

Population

118 consecutive patients with one-vessel disease undergoing percutaneous transluminal coronary angioplasty (PTCA) and systematic angiographic follow-up.

Intervention

ACE gene deletion polymorphism (DD or ID genotype)

Comparator

ACE gene insertion polymorphism (II genotype)

Outcome

Restenosis after PTCA (late luminal narrowing / late loss and >50% stenosis) assessed by quantitative coronary angiographysurrogate

The ACE gene I/D polymorphism does not appear to influence the risk of angiographic restenosis after coronary angioplasty.

Discussion

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Implication

ACE I/D polymorphism does not influence restenosis after PTCA; leaves open contributions from other genetic factors to post-angioplasty outcomes.

Cite This Study

Hamon et al. (1995) studied this question.

synapsesocial.com/papers/6a70461435aa2c282ce1929b https://doi.org/10.1161/01.cir.92.3.296

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Implication

ACE I/D polymorphism does not influence restenosis after PTCA; leaves open contributions from other genetic factors to post-angioplasty outcomes.

Relation Between the Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Late Luminal Narrowing After Coronary Angioplasty

Structured PICO

Discussion

Implication

Cite This Study

Relation Between the Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Late Luminal Narrowing After Coronary Angioplasty

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider