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Background: Alzheimer disease belonging to the class of neurodegenerative disorder which is characterized by the pathological accumulation of amyloid beta plaques and neurofibrillary tangles. About 4 percent people over age of 60 affected by AD Worldwide. The biosynthesis of lipid linked oligosaccharides takes place at the membrane of ER neurons and is characterized by the involvement of a special lipid carrier, dolichol. Dolichol kinase and GPT plays important role N glycosylation of APP. This study was done to investigate the effects of Dolichol kinase and GPT modulation in intracerebro ventricular Amyloid beta model in rat for improved memory cognition and function.
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Priyanka et al. (2018) studied this question.
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