Previous attempts to estimate the glycogen content of the human liver were based on deter- minations performed on material obtained by op- erative biopsy or from postmortem specimens. Observations on animals have shown that these procedures may introduce an important error through the effect of the commonly used anesthetic agents, or of trauma, before the specimen is ob- tained. The development of a technic for the re- moval of small specimens of liver by aspiration biopsy is well adapted to the study of glycogen metabolism, for it avoids the uncertain effects of premedication, general anesthesia and the trauma of operation. By this method serial biopsies of the liver have been obtained in a study of patients under treatment for diabetic acidosis.
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Bondy et al. (1949) studied this question.
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