February 11, 2009The FASEB Journal

skNAC (skeletal Naca), a muscle‐specific isoform of Naca (nascent polypeptide‐associated complex alpha), is required for myofibril organization

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Population

Zebrafish embryos

Comparison

Knockdown of sknac expression by antisense oligos vs Injection of a control oligo

Design

Preclinical

Authors

HLHuiqing LiKunming University of Science and Technology WRWilliam R. RandallUniversity of Maryland, Baltimore SDShaojun DuJiangnan University

Discussion

Member takes

Implication

skNAC essentiality in zebrafish myofibrillogenesis leaves open its relevance to human myopathies; mammalian validation required before any clinical consideration.

Structured PICO

Population

Zebrafish embryos

Intervention

Knockdown of sknac expression by antisense oligos

Comparator

Injection of a control oligo

Outcome

Myofibril assembly and function (muscle contraction, filament organization, myosin protein levels)surrogate

skNAC is essential for proper myofibril assembly and muscle function during differentiation in vivo.

Cite This Study

Li et al. (2009) studied this question.

synapsesocial.com/papers/6a7049c7a528af2d65c37041 https://doi.org/10.1096/fj.08-125542

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Implication

skNAC essentiality in zebrafish myofibrillogenesis leaves open its relevance to human myopathies; mammalian validation required before any clinical consideration.

skNAC (skeletal Naca), a muscle‐specific isoform of Naca (nascent polypeptide‐associated complex alpha), is required for myofibril organization

Discussion

Member takes

Implication

Structured PICO

Cite This Study

skNAC (skeletal Naca), a muscle‐specific isoform of Naca (nascent polypeptide‐associated complex alpha), is required for myofibril organization

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider