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May 16, 2018Journal of Neurology Neurosurgery & PsychiatryOpen Access

Acetazolamide can improve symptoms and signs in ion channel-related congenital myopathy

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Why the study?

Does acetazolamide improve symptoms and signs in individuals with ion channel-related congenital myopathy?

Population

Two individuals with ion channel-related congenital myopathy who had additional discrete episodic or…

Design

Case_series

Follow-up

long-term

Authors

EMEmma MatthewsLHLouise HartleyRSRicha Sud

Discussion

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Overview

Acetazolamide may improve symptoms in recessive ion channel myopathies; leaves open generalizability beyond this single case.

Structured PICO

Does acetazolamide improve symptoms and signs in individuals with ion channel-related congenital myopathy?

P
Population
Two individuals with ion channel-related congenital myopathy who had additional discrete episodic or fluctuant weakness
I
Intervention
Acetazolamide
O
Outcome
Improvement of symptoms and signs (long-term benefit)

Acetazolamide may provide long-term symptomatic benefit for patients with ion channel-related congenital myopathy experiencing episodic weakness.

Cite This Study

Matthews et al. (2018) studied this question.

synapsesocial.com/papers/6a704a5ac2d7c3090826e136https://doi.org/10.1136/jnnp-2017-317849
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sodium channel mutations in acetazolamide‐responsive myotonia congenita, paramyotonia congenita, and hyperkalemic periodic paralysis1994 · 158 citations
  2. 2Acetazolamide-responsive myotonia with a novel Ile239Thr mutation in SCN4A gene: a case report2024 · 1 citations
  3. 3Effects of acetazolamide on myotonia1978 · 69 citations
  4. 4Acetazolamide-Induced Weakness in Paramyotonia Congenita1977 · 25 citations
  5. 5Linkage of atypical myotonia congenita to a sodium channel locus1992 · 61 citations