Population
Human cell-line expressing SCN4A gene mutations associated with hypokalaemic periodic paralysis type II
Comparison
Changes in extra- or intracellular pH (low pH) vs Baseline/normal pH
Design
Preclinical
Authors
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May explain exercise benefits via pH in HypoPP2; hypothesis-generating for acetazolamide mechanisms before human translation.
Low pH alleviates inactivation defects in sodium channel mutations causing hypokalaemic periodic paralysis type II, providing a mechanistic explanation for the protective effect of mild exercise and a potential target for acetazolamide.
Kuzmenkin et al. (2002) studied this question.
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