Essential role of diastolic oscillatory potentials in adrenergic control of guinea pig sino-atrial node discharge
Population
Guinea pig sino-atrial node (SAN) preparations
Comparison
Adrenergic agonists, calcium load modulation… vs Baseline/control conditions
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Should not change If-directed sinus node therapies; leaves calcium-dependent mechanisms open for human validation.
Structured PICO
P
Population
Guinea pig sino-atrial node (SAN) preparations
I
Intervention
Adrenergic agonists (norepinephrine, isoproterenol), calcium load modulation, cesium, and barium
C
Comparator
Baseline/control conditions (non-spontaneous SAN, slowly discharging SAN, low calcium)
O
Outcome
Changes in diastolic oscillatory after-potential (Vos) and pre-potential (ThVos) and SAN discharge ratesurrogate
Adrenergic agonists initiate and enhance sino-atrial node pacemaker activity through calcium-dependent diastolic oscillatory potentials rather than the hyperpolarization-activated current If.
Cite This Study
Vassalle et al. (2009) studied this question.