Key result
Regulatory T cells counteract atherosclerosis initiation and progression by modulating pathogenic Th1 and Th2 pathways.
PURPOSE OF REVIEW: Atherosclerosis is an inflammatory disease of the arterial wall where both innate and adaptive Th1-driven immunoinflammatory responses contribute to disease development. Th2-related responses have been shown to be either protective or pathogenic. Thus, it is unclear whether immunoregulatory activity can modulate disease development. RECENT FINDINGS: Novel subtypes of T cells, called the regulatory T cells, have been shown recently to play a critical role in the maintenance of immunological tolerance against self and non-self antigens and prevent the development of various immunoinflammatory diseases. Preliminary studies suggest a potential role for this type of regulatory T cell response in atherosclerosis. SUMMARY: Here we present a novel view of the immunoinflammatory response in atherosclerosis where natural and/or adaptive regulatory T cell responses modulate both Th1 and Th2 pathogenic responses and play a central role in counteracting disease initiation and progression.
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Mallat et al. (2005) conducted a review in Atherosclerosis. Regulatory T cell responses was evaluated. Regulatory T cell responses modulate Th1 and Th2 pathogenic pathways, potentially playing a central role in counteracting the initiation and progression of atherosclerosis.
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