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February 1, 1999The Journal of Experimental MedicineOpen Access

CD8α+ and CD8α− Subclasses of Dendritic Cells Direct the Development of Distinct T Helper Cells In Vivo

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Authors

RMRoberto Maldonado-LópezUniversité Libre de BruxellesTSThibaut De SmedtUniversity of GenevaPMPatrick P. MichelCentre National de la Recherche Scientifique

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Implication

Randomized trial shows how dendritic cell subclasses influence T helper cell responses, suggesting key immune mechanisms.

Key Points

  • This research aims to investigate the role of CD8α+ and CD8α− dendritic cell subclasses in directing T helper cell development.
  • Dendritic cells were categorized based on CD8alpha expression and injected in syngeneic mice.
  • Antigen-pulsed CD8α+ and CD8α− dendritic cells were separated and used for in vivo priming of antigen-specific T cells.
  • The response of T helper cell populations was assessed after administration of CD8α+ and CD8α− dendritic cells.
  • Injection of CD8α− dendritic cells induced a Th2-type response.
  • Administration of CD8α+ dendritic cells led to Th1 differentiation.
  • Interleukin 12 was shown to be critical for Th1 development by CD8α+ dendritic cells.

Cite This Study

Maldonado-López et al. (1999) studied this question.

synapsesocial.com/papers/6a231c96386be3bc616569cehttps://doi.org/10.1084/jem.189.3.587
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Also Consider

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  1. 1Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.1986 · 7,554 citations
  2. 2Antigen localisation regulates immune responses in a dose‐ and time‐dependent fashion: a geographical view of immune reactivity1997 · 492 citations
  3. 3Fas transduces activation signals in normal human T lymphocytes.1993 · 528 citations
  4. 4In Vivo Microbial Stimulation Induces Rapid CD40 Ligand–independent Production of Interleukin 12 by Dendritic Cells and their Redistribution to T Cell Areas1997 · 922 citations
  5. 5Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1.1995 · 470 citations