Why the study?
How does elevation of intracranial pressure affect arterial baroreceptor reflex function in anesthetized cats?
How does elevation of intracranial pressure affect arterial baroreceptor reflex function in anesthetized cats?
Elevated intracranial pressure shifts the baroreceptor reflex curve upward, preventing blood pressure and flow resistance from returning to normal baseline levels despite baroreceptor activation.
Elevated ICP may limit baroreflex BP control in acute neuro settings; leaves open translation to human intracranial hypertension.
The ability of the arterial baroreceptor reflex to buffer the blood pressure responses elicited by increasing the intracranial pressure (ICP) has been studied in chloralose anesthetized cats. Standardized elevations of ICP induced pressor responses of similar magnitude irrespective of whether the baroreceptor inhibitory activity was high or vey low. When ICP was elevated baroreceptor activation induced a reflex reduction of flow resistance and blood pressure, but never to the same levels obtained when ICP was normal. Thus when ICP was elevated there was an upward displacement of the curve relating carotid sinus pressure to mean arterial blood pressure.
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Little et al. (1981) studied this question.
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