This review summarizes the clinical evidence for using argatroban and bivalirudin as alternatives to heparin during cardiac surgery and mechanical circulatory support.
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May guide heparin alternatives in cardiac surgery; leaves open optimal dosing and monitoring pending prospective trials.
Argatroban and bivalirudin are used as replacement anticoagulants for heparin. The authors review clinical studies for these drugs in the perioperative setting of cardiac surgical patients including extracorporeal management and mechanical support therapy.
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Koster et al. (2017) studied this question.
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