Why the study?
Does enoxaparin have a different effect on intravascular pools of tissue factor pathway inhibitor compared with unfractionated heparin in healthy male volunteers?
Population
18 healthy male volunteers
Comparison
Enoxaparin 1.5 mg/kg subcutaneous once daily for… vs Unfractionated heparin continuous i.v. infusion…
Design
RCT, randomly assigned
Follow-up
76 hours
Authors
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LMWH's TFPI preservation versus UFH depletion may favor its antithrombotic use; extends mechanistic distinctions in heparin RCTs.
Does enoxaparin have a different effect on intravascular pools of tissue factor pathway inhibitor compared with unfractionated heparin in healthy male volunteers?
Unlike unfractionated heparin, enoxaparin does not deplete intravascular pools of tissue factor pathway inhibitor, which may contribute to its superior antithrombotic efficacy.
Hansen et al. (1998) studied this question.
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