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June 1, 2026EP EuropaceOpen Access

Non-invasive mapping of the temporal stability of atrial high-rate activity predicts atrial fibrillation termination sites - the SAHRA multicenter trial

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Why the study?

Catheter ablation success rates in AF remain unsatisfactory partly due to limited understanding of individual AF mechanisms and lack of mapping systems capable of global beat-to-beat mapping with sufficient spatial resolution.

Does non-invasive SAHRA mapping accurately predict AF termination sites in patients undergoing AF ablation?

Population

185 consecutive AF-ablation patients presenting in AF

Design

Prospective European multicenter study

Authors

TAT F AlthoffILI LlorenteACA Costafreda

Discussion

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Member takes

Overview

Feasibility of high-resolution global AF mapping demonstrated; leaves open whether mechanism-guided ablation improves persistent AF outcomes.

Structured PICO

Does non-invasive SAHRA mapping accurately predict AF termination sites in patients undergoing AF ablation?

P
Population
185 consecutive AF-ablation patients presenting in atrial fibrillation
I
Intervention
Non-invasive global mapping using the Stability of Atrial High-Rate Activity (SAHRA) approach
O
Outcome
Prediction of AF termination sites (conversion to sinus rhythm or transition to organized flutter)surrogate

Non-invasive SAHRA mapping accurately identifies atrial sites critical for AF perpetuation, offering a potential tool to guide personalized AF ablation.

Cite This Study

Althoff et al. (2026) studied this question.

synapsesocial.com/papers/6a704d0bac440176ef28f47ahttps://doi.org/10.1093/europace/euag105.521
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Individual patterns of stable high-rate activity during atrial fibrillation are determined by local slow-conduction and predict arrhythmia recurrence - insights from non-invasive global mapping2026
  2. 2Non-invasive driver stability mapping predicts ablation sites of atrial fibrillation termination2025
  3. 3High-density mapping-based ablation strategies of cardiac rhythm disorders: the RHYTHMIA™ experience at new horizons2019 · 9 citations
  4. 4Simultaneous Whole-Chamber Non-contact Mapping of Highest Dominant Frequency Sites During Persistent Atrial Fibrillation: A Prospective Ablation Study2022 · 3 citations
  5. 5Atrial functional substrates for the prediction of atrial fibrillation recurrence after pulmonary vein isolation2023