Why the study?
Given the severity of the opioid epidemic, understanding the mechanisms of risk for development and maintenance of opioid use disorder is essential.
Does opioid use disorder associate with lower resting-state high-frequency heart rate variability in chronic pain patients on long-term opioid therapy?
Population
490 chronic pain patients treated with long-term opioid therapy
Comparison
Patients with OUD vs those without OUD
Design
Cross-sectional study
Authors
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HF-HRV may index autonomic dysregulation in OUD; leaves open causal links to craving and any clinical utility.
Does opioid use disorder associate with lower resting-state high-frequency heart rate variability in chronic pain patients on long-term opioid therapy?
Resting-state HF-HRV is significantly lower in chronic pain patients with opioid use disorder, suggesting it may serve as a biomarker of addiction in this population.
Roberts et al. (2022) studied this question.
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