What question did this study set out to answer?

To evaluate the efficacy and safety of imipenem-cilastatin as an initial empiric treatment for febrile episodes in cancer patients.

August 1, 1986Antimicrobial Agents and ChemotherapyOpen Access

Imipenem-cilastatin as initial therapy for febrile cancer patients

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Authors

GBGerald P. BodeyCreighton University MÁMaría E. ÁlvarezUniversidad de Alcalá PJPaula G. JonesSt George’s University Hospitals NHS Foundation Trust

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Implication

Clinical evaluation demonstrates high response rates with imipenem-cilastatin in febrile neutropenic cancer patients, highlighting its efficacy against severe bacterial infections.

Key Points

To evaluate the efficacy and safety of imipenem-cilastatin as an initial empiric treatment for febrile episodes in cancer patients.
Administered imipenem-cilastatin across 79 febrile episodes in 71 cancer patients, the majority of whom presented with neutropenia.
Evaluated therapeutic responses across 45 documented infections, including septicemia and pneumonia, and monitored adverse effects.
The overall response rate was 67% across all 79 febrile episodes, with 76% of the 45 documented infections responding favorably.
Response rates were 79% for septicemias and 62% for pneumonias, with only 1 of 17 gram-negative bacillary infections failing to respond.
Common adverse events included skin rash, nausea, and diarrhea, with 8 superinfections detected during treatment.

Cite This Study

Bodey et al. (1986) studied this question.

synapsesocial.com/papers/6a704e4fce524a4339c40e48 https://doi.org/10.1128/aac.30.2.211

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Implication

Clinical evaluation demonstrates high response rates with imipenem-cilastatin in febrile neutropenic cancer patients, highlighting its efficacy against severe bacterial infections.

Imipenem-cilastatin as initial therapy for febrile cancer patients

Discussion

Member takes

Implication

Key Points

Cite This Study

Imipenem-cilastatin as initial therapy for febrile cancer patients

Discussion

Member takes

Implication

Key Points

Cite This Study

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