Why the study?
Does the susceptibility of LDL to oxidation relate to endothelium-dependent coronary vasomotion in patients with hypercholesterolemia?
Population
23 patients with hypercholesterolemia, mean age 56 +/- 9 years
Comparison
1 year of therapy with either an American Heart… vs Comparison between the three treatment groups
Design
Cohort
Follow-up
1 year
Authors
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Reduced LDL oxidizability associates with preserved vasomotion; leaves open whether antioxidants improve endothelial function in hypercholesterolemia.
Does the susceptibility of LDL to oxidation relate to endothelium-dependent coronary vasomotion in patients with hypercholesterolemia?
In patients with hypercholesterolemia, the susceptibility of LDL to oxidation is an independent predictor of endothelium-dependent coronary vasomotion, suggesting oxidative stress contributes to endothelial dysfunction.
Anderson et al. (1996) studied this question.
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