What question did this study set out to answer?

To review the mechanisms and clinical significance of drug resistance across major antifungal classes in pathogenic Candida species.

October 1, 1986Journal of Antimicrobial Chemotherapy

Drug resistance in the opportunistic pathogens Candida albicans and Candida glabrata

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Authors

DKD. KerridgeBiogen (United States)RNRichard O. NicholasUniversity of Cambridge

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Implication

Narrative review outlines mechanisms of antifungal resistance in Candida albicans, indicating that loss of UMP pyrophosphorylase drives clinically significant failure.

Key Points

To review the mechanisms and clinical significance of drug resistance across major antifungal classes in pathogenic Candida species.
Evaluated mode of action and resistance development for polyene macrolides, synthetic imidazole derivatives, and 5-fluorocytosine.
Assessed fungal genetic mechanisms, including ploidy and mitotic segregation, underlying the emergence of drug resistance.
Mutants resistant to polyenes and imidazoles do not pose a major clinical problem due to organism diploidy and multifaceted membrane target interactions.
Resistance to 5-fluorocytosine represents a severe clinical issue driven by heterozygosity at the UMP pyrophosphorylase locus progressing to complete enzyme loss via mitotic segregation.

Cite This Study

Kerridge et al. (1986) studied this question.

synapsesocial.com/papers/6a704f0e75498292b709b7d6 https://doi.org/10.1093/jac/18.supplement_b.39

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Implication

Narrative review outlines mechanisms of antifungal resistance in Candida albicans, indicating that loss of UMP pyrophosphorylase drives clinically significant failure.

Drug resistance in the opportunistic pathogens Candida albicans and Candida glabrata

Discussion

Member takes

Implication

Key Points

Cite This Study

Drug resistance in the opportunistic pathogens Candida albicans and Candida glabrata

Discussion

Member takes

Implication

Key Points

Cite This Study

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