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Lipids in biological membranes are organized non-randomly across the bilayer. In eukaryotic cells, the cytoplasmic surface is enriched in anionic and primary amine-containing phospholipids (phosphoinositides (PIPn),2 phosphatidic acid, phosphatidylethanolamine (PE), phosphatidylserine (PS)), whereas the extracytoplasmic leaflet and the topologically equivalent lumenal surface of internal organelles are enriched in choline-containing phospholipids (phosphatidylcholine (PC) and sphingomyelin) and glycosphingolipids.
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David L. Daleke (2006) studied this question.
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