What question did this study set out to answer?

To develop and validate oPOSSUM-3, an online computational system for detecting over-represented transcription factor binding sites and families in co-expressed genes and high-throughput sequencing datasets.

September 1, 2012G3 Genes Genomes GeneticsOpen Access

oPOSSUM-3: Advanced Analysis of Regulatory Motif Over-Representation Across Genes or ChIP-Seq Datasets

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To develop and validate oPOSSUM-3, an online computational system for detecting over-represented transcription factor binding sites and families in co-expressed genes and high-throughput sequencing datasets.
Engineered a web-based platform to analyze DNA sequences of co-expressed genes and sequences generated from high-throughput technologies such as ChIP-Seq.
Benchmarked and validated the software using known reference sets of co-regulated genes alongside published ChIP-Seq experimental data.
Successfully identified mediating transcription factors and transcription factor binding site families across known co-regulated gene sets.
Demonstrated accurate detection of over-represented regulatory motifs from co-recovered sequences in published ChIP-Seq datasets.

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Implication

Computational validation demonstrates reliable transcription factor binding site detection across co-regulated genes and ChIP-Seq data, highlighting its utility for gene regulation analysis.

Cite This Study

Kwon et al. (2012) studied this question.

synapsesocial.com/papers/6a704f5df44fa9f079dde8d2 https://doi.org/10.1534/g3.112.003202

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Implication

Computational validation demonstrates reliable transcription factor binding site detection across co-regulated genes and ChIP-Seq data, highlighting its utility for gene regulation analysis.

oPOSSUM-3: Advanced Analysis of Regulatory Motif Over-Representation Across Genes or ChIP-Seq Datasets

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Discussion

Implication

Cite This Study

oPOSSUM-3: Advanced Analysis of Regulatory Motif Over-Representation Across Genes or ChIP-Seq Datasets

Key Points

Discussion

Implication

Cite This Study

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