What question did this study set out to answer?

To examine the effects of age and body mass index on sleep-disordered breathing, oxygen saturation, and sleep efficiency in patients with Prader-Willi syndrome.

March 27, 1995American Journal of Medical Genetics

Developmental trends of sleep‐disordered breathing in Prader‐Willi syndrome: The role of obesity

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Authors

GHGila HertzHuntington University MCMary CatalettoPulmonary and Allergy Associates SFSteven H. FeinsilverHofstra University

Discussion

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Implication

Cross-sectional study demonstrates that obesity drives sleep-disordered breathing in Prader-Willi syndrome across age groups, highlighting body mass index as the primary clinical target.

Key Points

To examine the effects of age and body mass index on sleep-disordered breathing, oxygen saturation, and sleep efficiency in patients with Prader-Willi syndrome.
Reviewed polysomnographic recordings from 43 children and adults with Prader-Willi syndrome categorized into five age groups.
Assessed changes in body mass index, nocturnal oxygen saturation, breathing parameters, and sleep efficiency index across cohorts using analysis of variance.
Body mass index increased significantly from early childhood to preadolescent groups and demonstrated an overall significant effect on breathing parameters and oxygen saturation, whereas age had no significant effect.
Higher body mass index was linked to lower oxygen saturation and an increased apnea/hypopnea index.
Sleep efficiency index was significantly reduced in adults compared to young children, preadolescents, and adolescents.

Cite This Study

Hertz et al. (1995) studied this question.

synapsesocial.com/papers/6a704ffaf44fa9f079dde9b9 https://doi.org/10.1002/ajmg.1320560215

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March 27, 1995American Journal of Medical Genetics

Developmental trends of sleep‐disordered breathing in Prader‐Willi syndrome: The role of obesity

View Full Paper

Ask AI

Bookmark

Authors

GHGila HertzHuntington University MCMary CatalettoPulmonary and Allergy Associates SFSteven H. FeinsilverHofstra University

Discussion

Member takes

Implication

Cross-sectional study demonstrates that obesity drives sleep-disordered breathing in Prader-Willi syndrome across age groups, highlighting body mass index as the primary clinical target.

Key Points

To examine the effects of age and body mass index on sleep-disordered breathing, oxygen saturation, and sleep efficiency in patients with Prader-Willi syndrome.
Reviewed polysomnographic recordings from 43 children and adults with Prader-Willi syndrome categorized into five age groups.
Assessed changes in body mass index, nocturnal oxygen saturation, breathing parameters, and sleep efficiency index across cohorts using analysis of variance.
Body mass index increased significantly from early childhood to preadolescent groups and demonstrated an overall significant effect on breathing parameters and oxygen saturation, whereas age had no significant effect.
Higher body mass index was linked to lower oxygen saturation and an increased apnea/hypopnea index.
Sleep efficiency index was significantly reduced in adults compared to young children, preadolescents, and adolescents.

Cite This Study

Hertz et al. (1995) studied this question.

synapsesocial.com/papers/6a704ffaf44fa9f079dde9b9 https://doi.org/10.1002/ajmg.1320560215

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