March 22, 2011HypertensionOpen Access

Angiotensin II Binding to Angiotensin I–Converting Enzyme Triggers Calcium Signaling

View Full Paper

Ask AI

Bookmark

Population

Chinese hamster ovary cells transfected with an ACE expression vector, and Tm5

Comparison

Angiotensin II vs Other ACE substrates/products or blockade with…

Design

Preclinical

Authors

PGPaola Bianchi GuimarãesUniversidade Federal de São Paulo ÉAÉrika Costa de AlvarengaUniversidade Federal de Juiz de Fora PSPaula D. Siqueira

Discussion

Member takes

Implication

Hypothesis-generating for an ACE-dependent Ang II pathway; requires confirmation in human models before clinical relevance.

Structured PICO

Population

Chinese hamster ovary cells transfected with an ACE expression vector, and Tm5 (a mouse melanoma cell line endogenously expressing ACE but not Ang II type 1 or type 2 receptors)

Intervention

Angiotensin II

Comparator

Other ACE substrates/products (Ang 1-7, bradykinin, bradykinin 1-5, N-acetyl-seryl-aspartyl-lysyl-proline) or blockade with lisinopril

Outcome

Activation of intracellular signaling pathways (inositol 1,4,5-trisphosphate and calcium mobilization)surrogate

Angiotensin II can directly interact with ACE to evoke calcium signaling independently of AT1 and AT2 receptors, revealing a novel mechanism of action within the renin-angiotensin system.

Cite This Study

Guimarães et al. (2011) studied this question.

synapsesocial.com/papers/6a705018febe604dd7091875 https://doi.org/10.1161/hypertensionaha.110.167171

View Full Paper

Ask AI

Bookmark

Angiotensin II Binding to Angiotensin I–Converting Enzyme Triggers Calcium Signaling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II Binding to Angiotensin I–Converting Enzyme Triggers Calcium Signaling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider