Population
Cardiac sarcoplasmic reticulum vesicles and purified cardiac ryanodine receptor (RyR2)
Comparison
MetabolicallyS-labeled calmodulin binding and… vs Skeletal muscle ryanodine receptor isoform
Design
Preclinical
Authors
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No immediate clinical implications; extends RyR2 regulation models but leaves open in vivo and disease relevance.
This basic science study elucidates the stoichiometry and regulatory mechanisms of calmodulin binding to the cardiac ryanodine receptor, highlighting significant differences from the skeletal muscle isoform.
Balshaw et al. (2001) studied this question.
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