October 8, 2001Journal of Medical Virology

Presumed common source outbreaks of hepatitis A in an endemic area confirmed by limited sequencing within the VP1 region

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Population

Hepatitis A cases from Central America, including isolates from outbreaks, sporadic cases, and hyper-endemic…

Design

Other

Authors

PAPatricia Arauz‐RuizSwedish Institute LSLena SundqvistPublic Health Agency of Sweden ZGZaida GarcíaCosta Rican Department of Social Security

Discussion

Member takes

Implication

May aid hepatitis A outbreak confirmation in endemic settings; hypothesis-generating pending prospective validation in broader populations.

Structured PICO

Population

Hepatitis A cases from Central America (Costa Rica and El Salvador), including isolates from outbreaks, sporadic cases, and hyper-endemic regions.

Intervention

Phylogenetic analysis using limited sequencing within the VP1 region.

Outcome

Differentiation of outbreak isolates from sporadic cases based on nucleotide variability.surrogate

Limited sequencing of the VP1 region is a useful molecular epidemiological tool to identify and confirm hepatitis A outbreaks in highly endemic areas.

Cite This Study

Arauz‐Ruiz et al. (2001) studied this question.

synapsesocial.com/papers/6a70511e5671bbf00bc2b010 https://doi.org/10.1002/jmv.2056

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Implication

May aid hepatitis A outbreak confirmation in endemic settings; hypothesis-generating pending prospective validation in broader populations.