Case Reports1 August 1941HISTOPLASMOSIS OF DARLING; REPORT OF A CASEROBERT B. WRIGHT, M.D., FRANK W. HACHTEL, M.D.ROBERT B. WRIGHT, M.D.Search for more papers by this author, FRANK W. HACHTEL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-15-2-309 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHistoplasmosis is a rare, anatomically widely disseminated, usually fatal fungus infection often characterized by fever, anemia, leukopenia and splenomegaly. The condition is caused by Histoplasma capsulatum which may be found in large numbers in the reticulo-endothelial cells and may be cultivated from the blood and other tissues. No specific therapy has been found. Mantell et al., as reported by Meleney,1 used a pentavalent antimony preparation (Neostam) possibly with some success.The fungus,H. capsulatum, has two forms. One is yeast-like and occurs in the blood and reticulo-endothelial cells. The other, the mycelial form, is assumed when it is grown outside...References1. MELENEY HE: Histoplasmosis (reticuloendothelial cytomycosis): a review, Am. Jr. Trop. Med., 1940, xx, 603-616. CrossrefGoogle Scholar2. DEMONBREUN WA: The cultivation and cultural characteristics of Darling's Histoplasma capsulatum , Am. Jr. Trop. Med., 1934, xiv, 93-125. CrossrefGoogle Scholar3. DEMONBREUN WA: The dog as a natural host for Histoplasma capsulatum , Am. Jr. Trop. Med., 1939, xix, 565-587. CrossrefGoogle Scholar4. DARLING ST: A protozoön general infection producing pseudo-tubercles in the lungs and focal necroses in the liver, spleen and lymph nodes, Jr. Am. Med. Assoc., 1906, xlvi, 1283-1285. CrossrefGoogle Scholar5. DARLING ST: Histoplasmosis: a fatal infectious disease resembling Kala-Azar found among natives of tropical America, Arch. Int. Med., 1908, ii, 107-123. CrossrefGoogle Scholar6. 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CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Received for publication April 4, 1941.From Departments of Pathology and Bacteriology of University of Maryland School of Medicine, Baltimore, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHistoplasmosisHistoplasmosis 1 August 1941Volume 15, Issue 2Page: 309-319KeywordsAnemiaAntimonyBacteriologyBlood cellsCellsFeversGratitudeHistoplasma capsulatumHistoplasmosisSplenomegaly ePublished: 1 December 2008 Issue Published: 1 August 1941 PDF downloadLoading ...
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