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August 19, 2022HealthcareOpen Access

uNGAL Predictive Value for Serum Creatinine Decrease in Critically Ill Children

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Why the study?

Serum creatinine elevation can be delayed by 48 h after renal injury, prompting evaluation of uNGAL alone and with the renal angina index to predict AKI development in critically ill children.

Does uNGAL measurement predict AKI development in critically ill children?

Comparison

uNGAL alone vs in association with the renal angina index

Authors

CGCristina GavriloviciCDCristian Petru DuşaCMCosmin Mihai

Discussion

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Member takes

Overview

uNGAL may enable earlier AKI detection in PICU children; leaves open need for outcome trials before routine adoption.

Structured PICO

Does uNGAL measurement predict AKI development in critically ill children?

P
Population
28 critically ill children aged from 1 day to 15 years admitted to the pediatric intensive care unit (PICU)
I
Intervention
Measurement of urinary neutrophil gelatinase-associated lipocalin (uNGAL) alone and in association with the renal angina index (RAI)
O
Outcome
Capacity to predict AKI developmentsurrogate

Limitations

  • Small sample size

Cite This Study

Gavrilovici et al. (2022) studied this question.

synapsesocial.com/papers/6a70523ca528af2d65c3754ahttps://doi.org/10.3390/healthcare10081575
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Urinary Neutrophil Gelatinase-Associated Lipocalin and Serum Cystatin C as Early Biomarkers of Acute Kidney Injury in Critically Ill Children: Single-Center PICU Cohort, 2024–20252026
  2. 245: LEVERAGING URINE BIOMARKERS TO PREDICT ACUTE KIDNEY INJURY IN CRITICALLY ILL CHILDREN2026
  3. 3Derivation and Validation of an Optimal Neutrophil Gelatinase-Associated Lipocalin Cutoff to Predict Stage 2/3 Acute Kidney Injury (AKI) in Critically Ill Children2024 · 33 citations
  4. 4Diagnostic utility of urinary neutrophil gelatinase associated lipocalin (µNGAL) in predicting the severity of acute kidney injury2025
  5. 5DIAGNOSTIC VALUE OF BIOMARKERS OF ACUTE KIDNEY INJURY DEVELOPMENT AFTER CARDIAC SURGERY PERFORMED IN THE CONDITIONS OF CARDIOPULMONARY BYPASS2021