Population
Native cardiac cells and NIH/3T3 cells overexpressing ClC-3 channels
Design
Preclinical
Authors
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May inform mechanistic studies of cardiac volume regulation; leaves open clinical relevance of serine51 in ClC-3.
Phosphorylation and dephosphorylation at the serine51 residue play a crucial role in regulating the volume sensitivity of ClC-3 chloride channels in cardiac and mammalian cells.
Duan et al. (1999) studied this question.
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