Why the study?
Do COX-2-selective NSAIDs reduce bleeding complications in concomitant coumarine users compared to non-selective NSAIDs?
Population
Concomitant coumarine and NSAID users
Comparison
COX-2-selective NSAIDs vs Non-selective NSAIDs
Design
Case-control
Follow-up
over two years
Authors
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Non-selective NSAIDs were associated with increased bleeding in coumarin users; leaves open whether COX-2-selective agents are safer.
Do COX-2-selective NSAIDs reduce bleeding complications in concomitant coumarine users compared to non-selective NSAIDs?
In patients taking coumarines, the use of COX-2-selective NSAIDs is associated with fewer bleeding complications compared to non-selective NSAIDs.
Knijff-Dutmer et al. (2003) studied this question.
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