Excitation-Transcription Coupling Mediated by Zinc Influx through Voltage-dependent Calcium Channels
Why the study?
Does zinc influx through L-type calcium channels mediate voltage-dependent gene expression in excitable cells?
Population
Heart cells and spontaneously depolarizing GH3 pituitary tumor cells
Comparison
Addition of extracellular Zn2+ and electrical… vs Exposure to dihydropyridine Ca2+ channel blockers
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Animal data raise possibility of dihydropyridine effects on gene expression; leaves open human translation in excitable cells.
Structured PICO
Does zinc influx through L-type calcium channels mediate voltage-dependent gene expression in excitable cells?
P
Population
Heart cells and spontaneously depolarizing GH3 pituitary tumor cells
I
Intervention
Addition of extracellular Zn2+ and electrical stimulation
C
Comparator
Exposure to dihydropyridine Ca2+ channel blockers
O
Outcome
Expression of a reporter gene driven by the metallothionein promotersurrogate
This study provides basic science evidence that zinc influx through L-type calcium channels can mediate voltage-dependent gene expression in excitable cells.
Cite This Study
Atar et al. (1995) studied this question.