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Glucocorticoids have been used for decades as immune suppressants to treat allergic reactions, reduce inflammation, and prevent rejection of transplanted organs. But how they work has been something of a mystery. Now, two teams of researchers report in Science that they appear to work by stimulating cells to produce a protein, which in turn binds and inactivates a second protein normally involved in turning on genes that orchestrate an immune response.
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Jean L. Marx (1995) studied this question.
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