Why the study?
Do nondipper normotensive individuals have higher mean platelet volume and atherogenic index of plasma compared to dippers?
Do nondipper normotensive individuals have higher mean platelet volume and atherogenic index of plasma compared to dippers?
Nondipper normotensive individuals exhibit higher mean platelet volume and atherogenic index of plasma, suggesting increased platelet activation and atherogenic risk despite normal blood pressure.
Nondipping may flag subclinical platelet and atherogenic risk in normotensives; leaves open whether it predicts events or warrants intervention.
Mean platelet volume (MPV) is a determinant of platelet activation. Atherogenic index of plasma (AIP), which is defined as the logarithm of the ratio of plasma level of triglycerides to the level of high-density lipoprotein (HDL)-cholesterol (log[ TG/HDL-C]), has recently been used as a marker of atherogenicity. This study included 104 normotensive individuals. Mean platelet volume and AIP were measured in all patients. Nondipper individuals (8.6 ± 0.9 fL, 0.3 ± 0.2) demonstrated higher values of MPV and AIP compared with dippers (7.9 ± 1.1 fL, 0.1 ± 0.2) (P < .001 and < .001, respectively). Mean platelet volume and AIP have a positive correlation with insufficient decline in nocturnal blood pressure.
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Yıldız et al. (2012) studied this question.
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