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Synthesizes 90 years of renin research; leaves open translation of intracellular mechanisms to clinical hypertension management.
Research on renin in the last 90 years has undergone numerous conceptual evolution since its discovery by Tigerstedt and Bergman in 1898. This paper briefly reviews the evolutionary steps leading up to the recently discovered intracellular function of renin and generation of angiotensin II in renin containing cells and molecular biological studies approaching the regulation of renin expression in various tissues.
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Inagami et al. (1988) studied this question.
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